Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283163 | 0.68 | LMNA (0.49) | ALDH1A1PDE4AHPGDMAPK1KDM4E | |
| SCHEMBL31030757 | 0.65 | PDE4A (0.45) | ALDH1A1PDE4AHPGDMAPK1KDM4E | |
| SCHEMBL8840880 | 0.65 | PDE4A (0.67) | ALDH1A1PDE4AHPGDMAPK1GAA | |
| SCHEMBL15816645 | 0.64 | NR3C1 (0.52) | ALDH1A1PTAFRNR3C1MAPK1GAA | |
| SCHEMBL31030696 | 0.64 | ALDH1A1 (0.44) | ALDH1A1PDE4AHPGDMAPK1KDM4E | |
| SCHEMBL9586738 | 0.63 | PTAFR (0.81) | PTAFRNR3C1MAPK1GAARAB9A | |
| SCHEMBL9586957 | 0.63 | PTAFR (0.81) | PTAFRNR3C1MAPK1GAARAB9A | |
| SCHEMBL28829958 | 0.62 | NR3C1 (0.53) | ALDH1A1PTAFRPDE4ANR3C1GAA | |
| SCHEMBL14590599 | 0.62 | PDE4A (0.41) | ALDH1A1PTAFRPDE4ANR3C1MAPK1 | |
| SCHEMBL28863320 | 0.62 | PTAFR (0.42) | ALDH1A1PTAFRPDE4ANR3C1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942641-A | TREATMENT OF ALZHEIMER'S DISEASE, NERVOUS SYSTEM DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-24 | — | — | US | disclosed |