Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.41 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30343291 | 0.83 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL599994 | 0.83 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Thiocyanic Acid SCHEMBL6501837 | 0.83 | NPC1 (0.54) | NPC1RAB9AATMVCAM1TDP1 | |
| SCHEMBL11694301 | 0.82 | NPC1 (0.62) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5158699 | 0.81 | NPC1 (0.62) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Bromide SCHEMBL5144105 | 0.80 | NPC1 (0.61) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6131224 | 0.80 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31173710 | 0.80 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| SCHEMBL23933293 | 0.79 | NPC1 (0.56) | NPC1RAB9AATMTDP1ALDH1A1 | |
| SCHEMBL741714 | 0.79 | NPC1 (0.62) | NPC1RAB9AATMTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476338-B1 | Polyviologen modified electrode and use thereof | DAISO CO LTD (JP) | 1999-11-03 | — | — | EP | disclosed |
| US-5232574-A | Water and solvent insolubility | DAISO CO. LTD. (JP) | 1993-08-03 | — | — | US | disclosed |
| EP-0476338-A2 | Polyviologen modified electrode and use thereof | DAISO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |