SCHEMBL8426259

SCHEMBL8426259

C=Cc1ccc(NC(=O)CCCl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.50
MAPT P10636 2/20 0.49
KDM4E B2RXH2 2/20 0.49
TP53 P04637 1/20 0.47
CASP3 P42574 1/20 0.44
CASP2 P42575 1/20 0.44
CASP7 P55210 1/20 0.44
CASP6 P55212 1/20 0.44
CASP8 Q14790 1/20 0.44
ALDH1A1 P00352 3/20 0.42
POLB P06746 3/20 0.42
HPGD P15428 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
NPC1 O15118 2/20 0.42
MITF O75030 2/20 0.42
RAB9A P51151 2/20 0.42
CYP1A1 P04798 1/20 0.42
XBP1 P17861 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8970273 0.89 THRB (0.40) THRBMAPTKDM4ETP53CASP3
SCHEMBL8428153 0.86 NPC1 (0.58) THRBMAPTKDM4ECASP3CASP2
SCHEMBL8433556 0.80 POLB (0.64) MAPTCASP3ALDH1A1POLBHPGD
SCHEMBL8970753 0.80 NPC1 (0.44) MAPTKDM4ETP53CASP3CASP2
SCHEMBL9113346 0.79 MAOB (0.45) THRBMAPTKDM4ETP53ALDH1A1
SCHEMBL13112978 0.79 POLB (0.46) THRBMAPTKDM4EALDH1A1POLB
SCHEMBL14593580 0.79 PRMT1 (0.42) THRBMAPTKDM4EALDH1A1HDAC1
SCHEMBL2205077 0.78 CYP1A1 (0.67) MAPTTP53CASP3CASP2CASP7
SCHEMBL1325326 0.78 ALDH1A1 (0.66) MAPTTP53ALDH1A1POLBHPGD
SCHEMBL8405243 0.78 PSMB11 (0.62) THRBMAPTTP53ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5429931-A Oxidized NAD, alcohol dehydrogenase, acrylic copolymer EASTMAN KODAK COMPANY (US) 1995-07-04 US claimed
EP-0626580-B1 Multilayer analytical element containing niacinamide and method for the determination of ethanol JOHNSON & JOHNSON CLIN DIAG (US) 1999-11-03 EP disclosed
EP-0476102-B1 CONTROL OF PRESSURE-FOG WITH GELATIN-GRAFTED AND CASE-HARDENED GELATIN-GRAFTED SOFT POLYMER LATEX PARTICLES EASTMAN KODAK CO (US) 1998-07-22 EP disclosed
EP-0478735-B1 USE OF GELATIN-GRAFTED AND CASE-HARDENED GELATIN-GRAFTED POLYMER PARTICLES FOR RELIEF FROM PRESSURE SENSITIVITY OF PHOTOGRAPHIC PRODUCTS EASTMAN KODAK CO (US) 1997-10-08 EP disclosed
EP-0572977-B1 Bilirubin assay using crosslinkable polymers JOHNSON & JOHNSON CLIN DIAG (US) 1997-08-13 EP disclosed
EP-0337785-B2 Diagnostic kit and method for rapid detection of antibodies JOHNSON & JOHNSON CLIN DIAG (US) 1996-03-13 EP disclosed
US-5429932-A Colorimetric analysis of ethanol EASTMAN KODAK COMPANY (US) 1995-07-04 US disclosed
US-5429931-A Oxidized NAD, alcohol dehydrogenase, acrylic copolymer EASTMAN KODAK COMPANY (US) 1995-07-04 US disclosed
US-5391483-A Using mixture of periodic acid and chromium trioxide EASTMAN KODAK COMPANY (US) 1995-02-21 US disclosed
US-5374516-A Covalently attached to polymer particles of ethylenically unsaturated monomers with reactive alkylsulfonyl or halogen groups; detecting hormones, drugs, steroids in urine, blood, saliva EASTMAN KODAK COMPANY (US) 1994-12-20 US disclosed
WO-1991014968-A1 CONTROL OF PRESSURE-FOG WITH GELATIN-GRAFTED AND CASE-HARDENED GELATIN-GRAFTED SOFT POLYMER LATEX PARTICLES EASTMAN KODAK COMPANY (US) 1991-10-03 WO disclosed
WO-1991014967-A1 USE OF GELATIN-GRAFTED AND CASE-HARDENED GELATIN-GRAFTED POLYMER PARTICLES FOR RELIEF FROM PRESSURE SENSITIVITY OF PHOTOGRAPHIC PRODUCTS EASTMAN KODAK COMPANY (US) 1991-10-03 WO disclosed
US-5026632-A Stress absorbing filler EASTMAN KODAK COMPANY (US) 1991-06-25 US disclosed
EP-0409977-A1 METHOD AND KIT FOR DETERMINATION OF HERPES SIMPLEX VIRAL ANTIGEN BY DIRECT BINDING TO POLYMERIC PARTICLES EASTMAN KODAK COMPANY (US) 1991-01-30 EP disclosed
WO-1990009593-A1 METHOD AND KIT FOR DETERMINATION OF HERPES SIMPLEX VIRAL ANTIGEN BY DIRECT BINDING TO POLYMERIC PARTICLES EASTMAN KODAK COMPANY (US) 1990-08-23 WO disclosed
US-4948480-A DISSOLVING ACRYLAMIDE COPOLYMER IN WATER, ADDING BUFFER, ADDING CROSSLINKING AGENT FROM SEPARATE PACKAGE EASTMAN KODAK COMPANY (US) 1990-08-14 US disclosed
EP-0347137-A2 Microporous article having a stabilized specific binding reagent, a method for its use and a diagnostic test kit EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-12-20 EP disclosed
EP-0340653-A2 Kit for electrophoresis gel medium EASTMAN KODAK COMPANY (US) 1989-11-08 EP disclosed
WO-1989009939-A1 COMPOSITIONS, DIAGNOSTIC KIT AND METHOD FOR RAPID DETECTION OF ANTIBODIES EASTMAN KODAK COMPANY (US) 1989-10-19 WO disclosed
EP-0337785-A1 Diagnostic kit and method for rapid detection of antibodies Johnson & Johnson Clinical Diagnostics, Inc. (US) 1989-10-18 EP disclosed