SCHEMBL8428153

SCHEMBL8428153

C=Cc1ccc(NC(=O)CCl)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
MITF O75030 2/20 0.58
XBP1 P17861 1/20 0.58
NPSR1 Q6W5P4 1/20 0.58
NOD2 Q9HC29 1/20 0.58
ALDH1A1 P00352 8/20 0.56
SMN1; SMN2 Q16637 7/20 0.56
HTT P42858 5/20 0.56
PRMT1 Q99873 1/20 0.56
MAPT P10636 6/20 0.51
KMT2A Q03164 5/20 0.51
LMNA P02545 4/20 0.51
KDM4E B2RXH2 3/20 0.51
MEN1 O00255 3/20 0.51
RNF4 P78317 1/20 0.51
CASP3 P42574 2/20 0.47
CASP2 P42575 1/20 0.47
HPGD P15428 2/20 0.45
OPRM1 P35372 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8970753 0.86 NPC1 (0.44) NPC1RAB9AMITFXBP1NPSR1
SCHEMBL8426259 0.86 THRB (0.50) NPC1RAB9AMITFXBP1NPSR1
SCHEMBL9081388 0.84 NPC1 (0.76) NPC1RAB9AMITFXBP1NPSR1
SCHEMBL6038006 0.83 NPC1 (0.59) NPC1RAB9AMITFXBP1NPSR1
SCHEMBL9113346 0.81 MAOB (0.45) ALDH1A1MAPTKMT2AKDM4EMEN1
SCHEMBL13112978 0.81 POLB (0.46) ALDH1A1MAPTKMT2AKDM4EMEN1
SCHEMBL832944 0.80 MAPT (0.57) ALDH1A1HTTMAPTKMT2ALMNA
SCHEMBL13101226 0.80 KMT2A (0.44) NPC1RAB9AALDH1A1MAPTKMT2A
SCHEMBL31703322 0.80 ALDH1A1 (0.54) NPC1RAB9AMITFXBP1NPSR1
SCHEMBL8430212 0.79 NPC1 (0.54) NPC1RAB9AMITFXBP1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104804724-B Ratio-type variant receptor mercury ion fluorescent probe and its preparation method and use 中国科学院大连化学物理研究所 2017-01-25 CN claimed
US-5429931-A Oxidized NAD, alcohol dehydrogenase, acrylic copolymer EASTMAN KODAK COMPANY (US) 1995-07-04 US claimed
EP-0419652-B1 POLYMERIC ELECTROPHORESIS MEDIA EASTMAN KODAK CO (US) 1994-01-05 EP claimed
EP-0340653-A2 Kit for electrophoresis gel medium EASTMAN KODAK COMPANY (US) 1989-11-08 EP claimed
CN-104804724-B Ratio-type variant receptor mercury ion fluorescent probe and its preparation method and use 中国科学院大连化学物理研究所 2017-01-25 CN disclosed
EP-0626580-B1 Multilayer analytical element containing niacinamide and method for the determination of ethanol JOHNSON & JOHNSON CLIN DIAG (US) 1999-11-03 EP disclosed
EP-0476102-B1 CONTROL OF PRESSURE-FOG WITH GELATIN-GRAFTED AND CASE-HARDENED GELATIN-GRAFTED SOFT POLYMER LATEX PARTICLES EASTMAN KODAK CO (US) 1998-07-22 EP disclosed
EP-0478735-B1 USE OF GELATIN-GRAFTED AND CASE-HARDENED GELATIN-GRAFTED POLYMER PARTICLES FOR RELIEF FROM PRESSURE SENSITIVITY OF PHOTOGRAPHIC PRODUCTS EASTMAN KODAK CO (US) 1997-10-08 EP disclosed
EP-0572977-B1 Bilirubin assay using crosslinkable polymers JOHNSON & JOHNSON CLIN DIAG (US) 1997-08-13 EP disclosed
EP-0337785-B2 Diagnostic kit and method for rapid detection of antibodies JOHNSON & JOHNSON CLIN DIAG (US) 1996-03-13 EP disclosed
US-5429932-A Colorimetric analysis of ethanol EASTMAN KODAK COMPANY (US) 1995-07-04 US disclosed
US-5429931-A Oxidized NAD, alcohol dehydrogenase, acrylic copolymer EASTMAN KODAK COMPANY (US) 1995-07-04 US disclosed
US-5026632-A Stress absorbing filler EASTMAN KODAK COMPANY (US) 1991-06-25 US disclosed
EP-0409977-A1 METHOD AND KIT FOR DETERMINATION OF HERPES SIMPLEX VIRAL ANTIGEN BY DIRECT BINDING TO POLYMERIC PARTICLES EASTMAN KODAK COMPANY (US) 1991-01-30 EP disclosed
WO-1990009593-A1 METHOD AND KIT FOR DETERMINATION OF HERPES SIMPLEX VIRAL ANTIGEN BY DIRECT BINDING TO POLYMERIC PARTICLES EASTMAN KODAK COMPANY (US) 1990-08-23 WO disclosed
US-4948480-A DISSOLVING ACRYLAMIDE COPOLYMER IN WATER, ADDING BUFFER, ADDING CROSSLINKING AGENT FROM SEPARATE PACKAGE EASTMAN KODAK COMPANY (US) 1990-08-14 US disclosed
EP-0347137-A2 Microporous article having a stabilized specific binding reagent, a method for its use and a diagnostic test kit EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-12-20 EP disclosed
EP-0340653-A2 Kit for electrophoresis gel medium EASTMAN KODAK COMPANY (US) 1989-11-08 EP disclosed
WO-1989009939-A1 COMPOSITIONS, DIAGNOSTIC KIT AND METHOD FOR RAPID DETECTION OF ANTIBODIES EASTMAN KODAK COMPANY (US) 1989-10-19 WO disclosed
EP-0337785-A1 Diagnostic kit and method for rapid detection of antibodies Johnson & Johnson Clinical Diagnostics, Inc. (US) 1989-10-18 EP disclosed