Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 14/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 18/20 | 0.53 |
| ▸ | AR | P10275 | 8/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425113 | 0.86 | PGR (0.51) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8427242 | 0.85 | PGR (0.81) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8423485 | 0.80 | PGR (0.73) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8425073 | 0.80 | PGR (0.49) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8424820 | 0.79 | PGR (0.55) | PGRNR3C1ARNR3C2 | |
| SCHEMBL8427264 | 0.78 | PGR (0.49) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8427053 | 0.77 | PGR (0.81) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8424832 | 0.75 | PGR (0.79) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8423175 | 0.75 | PGR (1.00) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8426848 | 0.75 | PGR (0.65) | PGRNR3C1ARCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582338-B1 | 17-Spiromethylene steroids | AKZO NOBEL NV (NL) | 1999-10-20 | — | — | EP | disclosed |
| US-5854235-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-12-29 | — | — | US | disclosed |
| US-5712264-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-01-27 | — | — | US | disclosed |
| EP-0582338-A2 | 17-Spiromethylene steroids | Akzo Nobel N.V. (NL) | 1994-02-09 | — | — | EP | disclosed |