Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25218344 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPK1MAPTNOTUM | |
| SCHEMBL19260129 | 0.79 | MAPT (0.49) | ALDH1A1KDM4EMAPK1MAPTTDP1 | |
| SCHEMBL5333636 | 0.79 | LMNA (0.52) | ALDH1A1KDM4EMAPK1MAPTTDP1 | |
| SCHEMBL31277054 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPK1MAPTNOTUM | |
| SCHEMBL4137682 | 0.79 | HPGD (0.51) | ALDH1A1KDM4EMAPK1MAPTHPGD | |
| SCHEMBL7473254 | 0.78 | FBP1 (0.46) | GRIA1GRIA2GRIA3GRIA4GRM6 | |
| SCHEMBL27853895 | 0.76 | MAPT (0.48) | ALDH1A1KDM4EMAPK1MAPTNOTUM | |
| SCHEMBL16150794 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPK1MAPTPOLB | |
| SCHEMBL7425462 | 0.76 | PDE2A (0.46) | GRIA1GRIA2GRIA3GRIA4GRM6 | |
| SCHEMBL25027362 | 0.76 | VCAM1 (0.46) | ALDH1A1MAPK1MAPTTDP1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955464-A | USE OF THE RECEPTOR TYROSINE KINASE INHIBITORY PROPERTIES OF THE COMPOUNDS IN THE TREATMENT OF PROLIFERATIVE DISEASE SUCH AS CANCER | ZENECA LIMITED (GB) | 1999-09-21 | — | — | US | disclosed |
| EP-0794953-B1 | QUINAZOLINE DERIVATIVES | ZENECA LTD (GB) | 1999-05-06 | — | — | EP | disclosed |
| EP-0794953-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016960-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |