SCHEMBL8427241

SCHEMBL8427241

O=S(=O)(c1ccccc1)c1ccc(-c2ccccc2Oc2ccccc2-c2ccc(S(=O)(=O)c3ccccc3)cc2S(=O)(=O)c2ccccc2)c(S(=O)(=O)c2ccccc2)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.41
POLB P06746 2/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 1/20 0.41
PTGS2 P35354 1/20 0.40
GAA P10253 1/20 0.38
GFER P55789 1/20 0.38
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
HTR2C P28335 2/20 0.38
HTR2B P41595 1/20 0.38
HTR2A P28223 1/20 0.38
KCNH2 Q12809 1/20 0.38
SFRP1 Q8N474 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
SCN9A Q15858 1/20 0.36
KIF18A Q8NI77 1/20 0.36
PNMT P11086 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9650276 0.85 HTR6 (0.58) HTR6POLBALDH1A1MAPTPTGS2
SCHEMBL8046886 0.79 HTR6 (0.45) HTR6SMN1; SMN2POLBALDH1A1MAPT
SCHEMBL8427238 0.74 HTT (0.51) HTR6SMN1; SMN2POLBALDH1A1MAPT
SCHEMBL8046997 0.72 HTR6 (0.69) HTR6SMN1; SMN2POLBALDH1A1MAPT
SCHEMBL28246658 0.72 POLB (0.53) HTR6SMN1; SMN2POLBALDH1A1MAPT
SCHEMBL10438260 0.72 MAOB (0.47) HTR6POLBMAPTPTGS2
SCHEMBL9793431 0.71 HTR6 (0.62) HTR6SMN1; SMN2POLBALDH1A1GAA
SCHEMBL8061985 0.71 HTR6 (0.56) HTR6SMN1; SMN2POLBALDH1A1MAPT
SCHEMBL8059453 0.70 GAA (0.47) SMN1; SMN2POLBALDH1A1MAPTGAA
SCHEMBL8058706 0.70 ALDH1A1 (0.47) POLBALDH1A1PTGS2GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791578-B1 Sulfonyl compound and thermalsensitive recording medium using the same SANKO KAIHATSU KAGAKU KENK (JP) 1999-11-10 EP claimed