Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437979 | 0.78 | MAPT (0.38) | MAPTHIF1A | |
| SCHEMBL8435374 | 0.69 | HIF1A (0.35) | MAPTHIF1A | |
| SCHEMBL9253576 | 0.66 | GABRA1 (0.37) | MAPTMEN1KMT2A | |
| SCHEMBL10382097 | 0.65 | MAOB (0.43) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8437513 | 0.62 | MAPT (0.31) | MAPT | |
| SCHEMBL9337494 | 0.61 | MAPT (0.44) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7202492 | 0.61 | MAPT (0.54) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6673193 | 0.61 | HTR2C (0.34) | LMNA | |
| SCHEMBL17771241 | 0.60 | HPGD (0.35) | MAPTLMNA | |
| SCHEMBL12076324 | 0.59 | MAPT (0.44) | MAPTHIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824522-B1 | 1,8-DIFLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | AVENTIS RES & TECH GMBH & CO (DE) | 1999-10-27 | — | — | EP | disclosed |
| US-5882546-A | 1,8-Difluorisoquinoline derivatives and the use thereof in liquid crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-16 | — | — | US | disclosed |