Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435374 | 0.86 | HIF1A (0.35) | MAPTESR1ESR2HIF1AALDH2 | |
| SCHEMBL8301789 | 0.79 | NR5A1 (0.36) | MAPTALDH2GAA | |
| SCHEMBL8427259 | 0.78 | MAPT (0.40) | MAPTHIF1A | |
| SCHEMBL9337494 | 0.70 | MAPT (0.44) | MAPTALDH2MAOAMAOBMGAM | |
| SCHEMBL10382097 | 0.68 | MAOB (0.43) | MAPTESR1ESR2ALDH2MAOA | |
| SCHEMBL8297766 | 0.68 | RAB9A (0.41) | MAPTGAA | |
| SCHEMBL8943288 | 0.65 | NPC1 (0.52) | MAPTALDH2MAOAMAOBMGAM | |
| SCHEMBL8437513 | 0.63 | MAPT (0.31) | MAPT | |
| SCHEMBL13978653 | 0.63 | GABRA1 (0.67) | MAPTESR1ESR2ALDH2GAA | |
| SCHEMBL9427345 | 0.63 | GABRA1 (0.39) | MAPTESR1ESR2ALDH2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825987-B1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | AVENTIS RES & TECH GMBH & CO (DE) | 1999-12-01 | — | — | EP | disclosed |
| US-5911913-A | 1-fluoroisoquinoline derivatives and the use thereof in liquid crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-06-15 | — | — | US | disclosed |
| EP-0825987-A1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996035674-A1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-14 | — | — | WO | disclosed |