Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437979 | 0.86 | MAPT (0.38) | HIF1AMAPTESR1ESR2ALDH2 | |
| SCHEMBL8299691 | 0.80 | RAB9A (0.44) | MAPTTDO2ESR1ESR2ALDH2 | |
| SCHEMBL9618499 | 0.72 | MAPT (0.46) | MAPTALDH2MAOAMAOBMGAM | |
| SCHEMBL8427259 | 0.69 | MAPT (0.40) | HIF1AMAPT | |
| SCHEMBL9618725 | 0.67 | GAA (0.44) | MAPTALDH2MAOAMAOBMGAM | |
| SCHEMBL8437415 | 0.66 | GABRA1 (0.42) | MAPTESR1ESR2ALDH2GAA | |
| SCHEMBL8423689 | 0.65 | MAPT (0.30) | MAPT | |
| SCHEMBL8440460 | 0.65 | MAPT (0.30) | HIF1AMAPT | |
| SCHEMBL9449606 | 0.64 | CYP11B1 (0.39) | MAPTESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL9278177 | 0.63 | SMN1; SMN2 (0.50) | MAPTHSD17B1HSD17B2ALDH2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825987-B1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | AVENTIS RES & TECH GMBH & CO (DE) | 1999-12-01 | — | — | EP | disclosed |
| EP-0824522-B1 | 1,8-DIFLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | AVENTIS RES & TECH GMBH & CO (DE) | 1999-10-27 | — | — | EP | disclosed |
| US-5911913-A | 1-fluoroisoquinoline derivatives and the use thereof in liquid crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-06-15 | — | — | US | disclosed |
| US-5882546-A | 1,8-Difluorisoquinoline derivatives and the use thereof in liquid crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-16 | — | — | US | disclosed |