Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428469 | 0.91 | RXRA (0.49) | RXRAPPARGLCKPDE2APTGS1 | |
| SCHEMBL8428330 | 0.90 | RXRA (0.48) | RXRAPPARGMAOB | |
| SCHEMBL8428373 | 0.87 | RXRA (0.39) | RXRAPPARGLCK | |
| SCHEMBL8430200 | 0.86 | MAOB (0.40) | RXRAPPARGMAOBLCK | |
| SCHEMBL8432133 | 0.81 | PPARG (0.45) | RXRAPPARGLCK | |
| SCHEMBL8428249 | 0.78 | MEN1 (0.35) | PPARGMAOB | |
| SCHEMBL24101814 | 0.77 | RXRA (0.54) | RXRAPPARG | |
| SCHEMBL30486786 | 0.77 | RXRA (0.54) | RXRAPPARG | |
| SCHEMBL8428468 | 0.77 | MEN1 (0.39) | RXRALCK | |
| SCHEMBL8430717 | 0.75 | RXRA (0.39) | RXRAPPARGPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |