Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.49 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428313 | 0.91 | RXRA (0.46) | RXRAPPARGPDE2ALCKPTGS1 | |
| SCHEMBL8428373 | 0.87 | RXRA (0.39) | RXRAPPARGLCKCYP1A2MAPT | |
| SCHEMBL8428330 | 0.86 | RXRA (0.48) | RXRAPPARGNR3C1 | |
| SCHEMBL8430200 | 0.86 | MAOB (0.40) | RXRAPPARGLCKMAPTMAPK1 | |
| SCHEMBL8432133 | 0.81 | PPARG (0.45) | RXRAPPARGLCKEGFRMAPT | |
| SCHEMBL8428249 | 0.78 | MEN1 (0.35) | PPARGEGFRMAPTMAPK1TDP1 | |
| SCHEMBL8428246 | 0.77 | RXRA (0.48) | RXRAPPARGLCKEGFRCYP1A2 | |
| SCHEMBL8428468 | 0.77 | MEN1 (0.39) | RXRALCKCYP1A2MAPTMAPK1 | |
| SCHEMBL25305589 | 0.75 | RXRA (0.46) | RXRAPPARG | |
| SCHEMBL8430717 | 0.75 | RXRA (0.39) | RXRAPPARGEGFRCYP1A2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |