Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 9/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428313 | 0.90 | RXRA (0.46) | RXRAPPARGMAOB | |
| SCHEMBL8428469 | 0.86 | RXRA (0.49) | RXRAPPARGNR3C1 | |
| SCHEMBL8432133 | 0.86 | PPARG (0.45) | RXRAPPARG | |
| SCHEMBL8428373 | 0.81 | RXRA (0.39) | RXRAPPARG | |
| SCHEMBL8430200 | 0.80 | MAOB (0.40) | RXRAPPARGMAOBMAOA | |
| SCHEMBL8430806 | 0.78 | RXRA (0.53) | RXRAPPARGMAOBMAOAAKR1C3 | |
| SCHEMBL8428249 | 0.78 | MEN1 (0.35) | PPARGMAOB | |
| SCHEMBL24101890 | 0.74 | PPARG (0.50) | RXRAPPARG | |
| SCHEMBL30095360 | 0.74 | PPARG (0.50) | RXRAPPARG | |
| SCHEMBL25305480 | 0.74 | RXRA (0.50) | RXRAPPARGNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |