Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428373 | 0.89 | RXRA (0.39) | PPARGMEN1MAPTHPGDKMT2A | |
| SCHEMBL8428330 | 0.86 | RXRA (0.48) | PPARGRXRA | |
| SCHEMBL8428249 | 0.84 | MEN1 (0.35) | PPARGRELAMEN1ALDH1A1MAPT | |
| SCHEMBL8430200 | 0.82 | MAOB (0.40) | PPARGMEN1MAPTKMT2ALCK | |
| SCHEMBL8428469 | 0.81 | RXRA (0.49) | PPARGMAPTLCKEGFRRXRA | |
| SCHEMBL8428313 | 0.81 | RXRA (0.46) | PPARGLCKRXRA | |
| SCHEMBL8428468 | 0.79 | MEN1 (0.39) | MEN1MAPTHPGDKMT2ALCK | |
| SCHEMBL8428198 | 0.77 | PPARG (0.50) | PPARGRELAMEN1ALDH1A1MAPT | |
| SCHEMBL8430717 | 0.77 | RXRA (0.39) | PPARGMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL24101890 | 0.77 | PPARG (0.50) | PPARGMEN1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |