Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 6/20 | 0.36 |
| ▸ | APP | P05067 | 4/20 | 0.36 |
| ▸ | SNCA | P37840 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432071 | 0.85 | PPARG (0.41) | PPARGMAPTALDH1A1RXRACYP1A2 | |
| SCHEMBL8432108 | 0.85 | RXRA (0.51) | PPARGMAPTALDH1A1GAARXRA | |
| SCHEMBL8430314 | 0.83 | PPARG (0.39) | PPARGMAPTALDH1A1RXRACYP1A2 | |
| SCHEMBL8432124 | 0.82 | MAOB (0.45) | PPARGMAPTALDH1A1GAARXRA | |
| SCHEMBL8428259 | 0.81 | PPARG (0.38) | PPARGMAPTALDH1A1RXRACYP1A2 | |
| SCHEMBL8430723 | 0.81 | RXRA (0.43) | PPARGMAPTGAARXRAMAOB | |
| SCHEMBL8431832 | 0.80 | AMY1A (0.43) | PPARGMAPTALDH1A1GAARXRA | |
| SCHEMBL8432651 | 0.78 | MAPT (0.32) | MAPTALDH1A1GAARXRAAPP | |
| SCHEMBL11761278 | 0.77 | PDGFRB (0.34) | PPARGMAPTALDH1A1RXRAAPP | |
| SCHEMBL8431725 | 0.76 | RXRA (0.36) | PPARGMAPTALDH1A1RXRAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |