Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428198 | 0.88 | PPARG (0.50) | RXRAPPARGLCKMEN1MAPT | |
| SCHEMBL8432124 | 0.86 | MAOB (0.45) | RXRAPPARGLCKMEN1GAA | |
| SCHEMBL8154649 | 0.86 | RXRA (0.44) | RXRAPPARGLCKMEN1GAA | |
| SCHEMBL8154646 | 0.86 | RXRA (0.44) | RXRAPPARGLCKMEN1GAA | |
| SCHEMBL8432071 | 0.85 | PPARG (0.41) | RXRAPPARGMEN1MAPTKMT2A | |
| SCHEMBL8428246 | 0.85 | RXRA (0.48) | RXRAPPARGLCKMEN1MAPT | |
| SCHEMBL8430314 | 0.83 | PPARG (0.39) | RXRAPPARGLCKMEN1MAPT | |
| SCHEMBL8432058 | 0.83 | PPARG (0.40) | RXRAPPARGLCKMAPT | |
| SCHEMBL8431908 | 0.82 | LCK (0.38) | RXRALCKMAPTABCG2PRKACA | |
| SCHEMBL8432304 | 0.82 | AR (0.40) | PPARGMEN1MAPTKMT2AABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |