Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | APP | P05067 | 5/20 | 0.41 |
| ▸ | SNCA | P37840 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430723 | 0.86 | RXRA (0.43) | MAOBMAPTPPARGRXRAGAA | |
| SCHEMBL8428246 | 0.83 | RXRA (0.48) | MAPTPPARGRXRAALDH1A1MEN1 | |
| SCHEMBL19862422 | 0.82 | PPARG (0.60) | MAOBMAOAMAPTPPARGRXRA | |
| SCHEMBL21805849 | 0.82 | PPARG (0.60) | MAOBMAOAMAPTPPARGRXRA | |
| SCHEMBL8428736 | 0.82 | PPARG (0.38) | MAOBMAOAMAPTAPPSNCA | |
| SCHEMBL8432058 | 0.81 | PPARG (0.40) | MAPTPPARGRXRAMAPK1LCK | |
| SCHEMBL8428198 | 0.79 | PPARG (0.50) | MAOBMAOAMAPTPPARGRXRA | |
| SCHEMBL8432108 | 0.79 | RXRA (0.51) | MAPTAPPSNCAPPARGRXRA | |
| SCHEMBL17847838 | 0.77 | RXRA (0.46) | MAOBMAOAMAPTAPPSNCA | |
| SCHEMBL17847842 | 0.77 | RXRA (0.46) | MAOBMAOAMAPTAPPSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |