Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442139 | 0.94 | KMT2A (0.66) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8428854 | 0.91 | ALDH1A1 (0.61) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7656840 | 0.83 | CA12 (0.52) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11807890 | 0.79 | ALDH1A1 (0.65) | KMT2AMAPTALDH1A1SMN1; SMN2CA12 | |
| SCHEMBL8428857 | 0.79 | ALDH1A1 (0.56) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3345207 | 0.79 | CA12 (0.68) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL742343 | 0.78 | KMT2A (0.71) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11211724 | 0.78 | ALDH1A1 (0.55) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4026040 | 0.78 | KMT2A (0.79) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29591107 | 0.78 | KMT2A (0.79) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861412-A | CARDIOPROTECTIVE AGENTS, CEREBROPROTECTIVE AGENTS, AGENTS FOR TREATING CHRONIC INFLAMMATORY PROCESSES, ANTIPROLIFERATIVE AGENTS AND AS AGENTS FOR TREATING ULCERATIVE COLITIS AND CROHN'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1999-01-19 | — | — | US | disclosed |
| US-5674878-A | ANTIPROLIFERATIVE,-TUMOR AND -CARCINOGENIC AGENTS; ULCERATIVE COLITIS; CROHN*S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1997-10-07 | — | — | US | disclosed |
| US-5643919-A | TREATMENT OF CROHN*S DISEASE, ULCERATIVE COLITIS | BOEHRINGER INGELHEIM KG (DE) | 1997-07-01 | — | — | US | disclosed |