Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432437 | 0.90 | RXFP1 (0.38) | RXFP1KCNK3KCNK9CYP1A2CYP3A4 | |
| SCHEMBL8428895 | 0.88 | TRPV4 (0.35) | RXFP1KCNK9CYP1A2CYP3A4MAPT | |
| SCHEMBL8429055 | 0.88 | TRPV4 (0.35) | RXFP1KCNK9CYP1A2CYP3A4MAPT | |
| SCHEMBL8431235 | 0.82 | RXFP1 (0.32) | RXFP1KCNK3KCNK9CYP1A2CYP3A4 | |
| SCHEMBL8432619 | 0.79 | TRPV4 (0.35) | RXFP1MAPTTRPV4POLB | |
| SCHEMBL8432441 | 0.79 | KMT2A (0.32) | RXFP1CYP1A2POLBKMT2A | |
| SCHEMBL8430960 | 0.78 | MAPT (0.35) | RXFP1CYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL8431435 | 0.76 | CA1 (0.32) | RXFP1KCNK3MAPTMAPK1KMT2A | |
| SCHEMBL8430873 | 0.75 | KMT2A (0.32) | RXFP1KCNK9POLBKMT2A | |
| SCHEMBL8430969 | 0.75 | NR1H4 (0.33) | KCNK9CYP1A2CYP3A4MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |