Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429207 | 0.89 | P2RX1 (0.36) | CYP2C19CYP3A4CYP2C9HPGDCYP1A2 | |
| SCHEMBL8431435 | 0.87 | CA1 (0.32) | RAB9AKMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL8429055 | 0.86 | TRPV4 (0.35) | KCNK9CYP2C19CYP3A4KMT2ACYP1A2 | |
| SCHEMBL8431235 | 0.86 | RXFP1 (0.32) | KCNK9CYP2C19CYP3A4RAB9AKMT2A | |
| SCHEMBL8429290 | 0.83 | CA1 (0.33) | KCNK9CYP2C19CYP3A4RAB9AKMT2A | |
| SCHEMBL8430960 | 0.83 | MAPT (0.35) | CYP2C19CYP3A4HPGDRAB9AKMT2A | |
| SCHEMBL8432441 | 0.83 | KMT2A (0.32) | RAB9AKMT2ACYP1A2SMN1; SMN2LMNA | |
| SCHEMBL8429159 | 0.82 | NR1H4 (0.32) | NR1H4HPGDRAB9AKMT2AALDH1A1 | |
| SCHEMBL8432619 | 0.81 | TRPV4 (0.35) | HPGDRAB9AALDH1A1MAPT | |
| SCHEMBL8521199 | 0.81 | ALDH1A1 (0.36) | HPGDRAB9AKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |