Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532986 | 0.87 | PTGER4 (0.42) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8429309 | 0.81 | FFAR1 (0.37) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8532998 | 0.74 | PTGER4 (0.42) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL4109710 | 0.70 | FFAR1 (0.53) | MAPTFFAR4FFAR1ITGB1ITGB3 | |
| SCHEMBL7378803 | 0.70 | ITGB3 (0.50) | MAPTPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4110638 | 0.68 | NR1H4 (0.55) | MAPTFFAR1ITGB3ITGA2BNR1H4 | |
| Hydrochloric Acid SCHEMBL10360584 | 0.67 | NR1H4 (0.53) | MAPTFFAR1ITGB3ITGA2BNR1H4 | |
| SCHEMBL8531196 | 0.66 | PTGER4 (0.43) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| Acetic Acid SCHEMBL27357776 | 0.65 | MAPT (0.55) | MAPTKDM4E | |
| SCHEMBL4104207 | 0.64 | ITGB3 (0.53) | MAPTFFAR1ITGB3ITGA2BNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |