Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546801 | 0.88 | THRB (0.39) | THRBPPARD | |
| Ethylene SCHEMBL28562789 | 0.86 | THRB (0.38) | THRBPPARD | |
| Tromethamine SCHEMBL5319864 | 0.80 | ALDH1A1 (0.33) | PPARDS1PR1S1PR3 | |
| SCHEMBL21612676 | 0.79 | THRB (0.33) | THRB | |
| Biphenyl SCHEMBL8757677 | 0.76 | MEN1 (0.38) | — | |
| SCHEMBL5720290 | 0.76 | BTN3A1 (0.37) | THRBPPARD | |
| SCHEMBL7912998 | 0.75 | BTN3A1 (0.39) | THRB | |
| SCHEMBL18043471 | 0.75 | TSHR (0.40) | THRB | |
| SCHEMBL5720294 | 0.75 | TSHR (0.36) | THRBPPARD | |
| SCHEMBL19138677 | 0.73 | THRB (0.38) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866298-A | Radiation sensitive composition for color filters | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0775941-A1 | Radiation sensitive composition for color filters | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |