Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716289 | 0.94 | PPARG (0.48) | PPARGPPARAALDH1A1HPGDHTT | |
| SCHEMBL8716282 | 0.93 | PPARG (0.47) | PPARGPPARAALDH1A1HPGDHTT | |
| SCHEMBL7830197 | 0.86 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL4744468 | 0.82 | PPARG (0.63) | PPARGPPARA | |
| SCHEMBL8719648 | 0.82 | ALDH1A1 (0.48) | PPARGALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL7826285 | 0.79 | PPARG (0.68) | PPARGPPARA | |
| SCHEMBL14188640 | 0.78 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL8431283 | 0.77 | PPARG (0.50) | PPARGPPARA | |
| SCHEMBL6802249 | 0.77 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL8716801 | 0.76 | NPC1 (0.47) | PPARGPPARAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869495-A | TREATMENT AND/OR PROPHYLAXIS OF HYPERGLYCAEMIA | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-02-09 | — | — | US | disclosed |
| US-5756525-A | USING A THIAZOLIDINEDIONE COMPOUND | BEECHAM GROUP PLC (GB) | 1998-05-26 | — | — | US | disclosed |