Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429671 | 0.82 | NPC1 (0.40) | NPC1ALDH1A1GAAPPARGPPARA | |
| SCHEMBL8429668 | 0.76 | PPARG (0.53) | ALDH1A1PPARGPPARASMN1; SMN2 | |
| SCHEMBL8719666 | 0.76 | ALDH1A1 (0.40) | NPC1ALDH1A1GAALMNAKMT2A | |
| SCHEMBL8719479 | 0.76 | ALOX15 (0.42) | NPC1ALDH1A1GAALMNAKMT2A | |
| SCHEMBL8716289 | 0.75 | PPARG (0.48) | NPC1ALDH1A1PPARGPPARAPPARD | |
| SCHEMBL8716282 | 0.74 | PPARG (0.47) | NPC1ALDH1A1PPARGPPARASMN1; SMN2 | |
| SCHEMBL17513806 | 0.68 | ALDH1A1 (0.48) | NPC1ALDH1A1GAALMNAKMT2A | |
| SCHEMBL535646 | 0.67 | ALDH1A1 (0.73) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL31401930 | 0.67 | ALDH1A1 (0.73) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL10431312 | 0.67 | SMN1; SMN2 (0.45) | NPC1ALDH1A1GAALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756525-A | USING A THIAZOLIDINEDIONE COMPOUND | BEECHAM GROUP PLC (GB) | 1998-05-26 | — | — | US | disclosed |