Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10736372 | 0.91 | ALDH1A1 (0.41) | AKR1C3ALDH1A1TSHRMIFCES2 | |
| SCHEMBL15572316 | 0.89 | AKR1C3 (0.58) | AKR1C3 | |
| SCHEMBL8603397 | 0.88 | AKR1C3 (0.47) | AKR1C3MIFCES2 | |
| SCHEMBL15570465 | 0.82 | AKR1C3 (0.39) | AKR1C3ALDH1A1MIFCES2BCHE | |
| SCHEMBL8435180 | 0.81 | AKR1C3 (0.49) | AKR1C3ALDH1A1MIFCES2SMN1; SMN2 | |
| SCHEMBL10603244 | 0.79 | CA2 (0.46) | ALDH1A1MIFCES2 | |
| SCHEMBL8430293 | 0.78 | MIF (0.39) | AKR1C3MIFCES2SMN1; SMN2METAP1 | |
| SCHEMBL8430753 | 0.77 | AKR1C2 (0.43) | AKR1C3ALDH1A1MIFCES2MAPT | |
| SCHEMBL8796288 | 0.77 | AKR1C3 (0.48) | AKR1C3 | |
| SCHEMBL2224238 | 0.74 | AKR1C3 (0.47) | AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |