Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430723 | 0.88 | RXRA (0.43) | PPARGMEN1HPGDKMT2AMAPT | |
| SCHEMBL8432304 | 0.81 | AR (0.40) | PPARGMEN1KMT2AMAPTRELA | |
| SCHEMBL8432124 | 0.79 | MAOB (0.45) | PPARGMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL8428246 | 0.78 | RXRA (0.48) | PPARGMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL8432133 | 0.77 | PPARG (0.45) | PPARGMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL8432058 | 0.76 | PPARG (0.40) | PPARGMAPTLCKEGFRRXRA | |
| SCHEMBL8154649 | 0.74 | RXRA (0.44) | PPARGMEN1HPGDKMT2AMAPT | |
| SCHEMBL8154646 | 0.74 | RXRA (0.44) | PPARGMEN1HPGDKMT2AMAPT | |
| SCHEMBL8432071 | 0.73 | PPARG (0.41) | PPARGMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL8155194 | 0.73 | PPARG (0.52) | PPARGMEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |