Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380583 | 0.85 | GPR132 (0.39) | ALDH1A1SMN1; SMN2GPR132SLC7A5 | |
| SCHEMBL7380590 | 0.85 | GPR132 (0.39) | ALDH1A1SMN1; SMN2GPR132SLC7A5 | |
| SCHEMBL7376071 | 0.82 | ITGB3 (0.39) | MEN1KMT2AALDH1A1GPR132SLC7A5 | |
| SCHEMBL7376076 | 0.82 | ITGB3 (0.39) | MEN1KMT2AALDH1A1GPR132SLC7A5 | |
| SCHEMBL7375578 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2GPR132 | |
| SCHEMBL7375584 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2GPR132 | |
| SCHEMBL7375604 | 0.81 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2GPR132 | |
| SCHEMBL7375609 | 0.81 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2GPR132 | |
| SCHEMBL7466500 | 0.79 | ITGB3 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2GPR132 | |
| SCHEMBL7409609 | 0.79 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1SMN1; SMN2GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |