Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 8/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PROC | P04070 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531077 | 0.89 | PRSS1 (0.43) | PTGER4PTGER3PTGER1PTGER2PRSS1 | |
| SCHEMBL8432519 | 0.85 | PTGER4 (0.45) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8429218 | 0.83 | PTGER4 (0.45) | PTGER4PTGER3PTGER1PTGER2PRSS1 | |
| SCHEMBL8430865 | 0.82 | PTGER4 (0.47) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8534458 | 0.79 | F10 (0.43) | PRSS1PRSS2PRSS3F10F2 | |
| SCHEMBL8428906 | 0.74 | ITGB3 (0.39) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8429316 | 0.74 | ITGB3 (0.39) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8530521 | 0.73 | ENPP2 (0.47) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8432900 | 0.73 | PTGER4 (0.40) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8531192 | 0.72 | PTGER4 (0.48) | PTGER4PTGER3PTGER1PTGER2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |