Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.36 |
| ▸ | UBE2M | P61081 | 2/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432475 | 0.89 | RAB9A (0.42) | RAB9ACASRUSP2UBE2MDCUN1D1 | |
| SCHEMBL8431238 | 0.82 | RAB9A (0.39) | KMT2ARAB9ACASRUSP2CRHBP | |
| SCHEMBL8430868 | 0.82 | RAB9A (0.41) | RAB9AUSP2CRHBPCRHR2LTA4H | |
| SCHEMBL8431173 | 0.76 | CTSD (0.35) | RAB9AUSP2UBE2MDCUN1D1LTA4H | |
| SCHEMBL8431230 | 0.76 | RAB9A (0.40) | KMT2ARAB9AUSP2CRHBPCRHR2 | |
| SCHEMBL8431034 | 0.74 | ALDH1A1 (0.41) | HSD17B10RAB9AUSP2UBE2MDCUN1D1 | |
| SCHEMBL8429288 | 0.73 | CA2 (0.38) | RAB9AUSP2CRHBPCRHR2LTA4H | |
| SCHEMBL8428881 | 0.73 | PLAU (0.34) | PKMHSD17B10ALDH1A1 | |
| SCHEMBL8432438 | 0.73 | RAB9A (0.37) | RAB9AUSP2SIRT2CRHBPCRHR2 | |
| SCHEMBL8431432 | 0.72 | RAB9A (0.36) | KMT2ARAB9AUSP2SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |