Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | FABP1 | P07148 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532447 | 0.83 | PTGS1 (0.40) | SRD5A2ABCB11LMNAPTGS1ADORA1 | |
| SCHEMBL8530525 | 0.82 | ABCB11 (0.54) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL8532340 | 0.82 | PTGS1 (0.39) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL8432815 | 0.79 | ITGB3 (0.40) | LMNAMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL8429321 | 0.76 | ITGB3 (0.38) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL8432903 | 0.75 | ITGB3 (0.39) | SRD5A2ABCB11LMNAPTGS1ADORA1 | |
| SCHEMBL8429187 | 0.75 | ITGB3 (0.37) | FFAR1CA1CA2 | |
| SCHEMBL8431244 | 0.74 | ITGB3 (0.37) | PTGS1PTGS2FFAR1CA1CA2 | |
| SCHEMBL8432521 | 0.74 | ABCB11 (0.41) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL8428908 | 0.74 | ITGB3 (0.38) | SRD5A2MEN1KMT2AFFAR1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |