SCHEMBL8432808

SCHEMBL8432808

CCCCCCCCCCCCOC(CCN)OCCCCCCCCCCCC

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DNM1 Q05193 9/20 0.55
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
ALDH1A1 P00352 1/20 0.44
TSHR P16473 1/20 0.44
EPHX1 P07099 1/20 0.44
CA1 P00915 8/20 0.42
CA2 P00918 8/20 0.42
CA9 Q16790 7/20 0.42
CA12 O43570 3/20 0.42
CA7 P43166 3/20 0.42
CA14 Q9ULX7 3/20 0.42
CA3 P07451 2/20 0.42
CA4 P22748 2/20 0.42
CA6 P23280 2/20 0.42
CA5A P35218 2/20 0.42
CA5B Q9Y2D0 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4275158 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL4271916 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL10384072 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL4280442 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL1817035 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL4275678 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL27815332 1.00 DNM1 (0.55) DNM1MEN1KMT2AALDH1A1TSHR
Bromide SCHEMBL5500592 0.98 DNM1 (0.53) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL6577557 0.91 DNM1 (0.43) DNM1MEN1KMT2AALDH1A1TSHR
SCHEMBL3244710 0.89 DNM1 (0.53) DNM1MEN1KMT2AALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11963982-B2 CRISPR/RNA-guided nuclease systems and methods EDITAS MEDICINE, INC. (US) 2024-04-23 US disclosed
EP-4126039-A1 TREATMENT INVOLVING NON-IMMUNOGENIC RNA FOR ANTIGEN VACCINATION BioNTech SE (DE) 2023-02-08 EP disclosed
US-20210371858-A1 METHODS OF SUPPRESSING PATHOGENIC MUTATIONS USING PROGRAMMABLE BASE EDITOR SYSTEMS BEAM THERAPEUTICS INC. (US) 2021-12-02 US disclosed
WO-2021198258-A1 TREATMENT INVOLVING NON-IMMUNOGENIC RNA FOR ANTIGEN VACCINATION BioNTech SE (DE) 2021-10-07 WO disclosed
US-20200155606-A1 CRISPR/RNA-GUIDED NUCLEASE SYSTEMS AND METHODS EDITAS MEDICINE, INC. (US) 2020-05-21 US disclosed
EP-0954339-A2 CATIONIC AMPHIPHILE COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC MOLECULES Genzyme Corporation (US) 1999-11-10 EP disclosed
WO-1998002191-A2 CATIONIC AMPHIPHILE COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC MOLECULES GENZYME CORPORATION (US) 1998-01-22 WO disclosed
US-4757144-A Adding aqueous or methanolic solution of formaldehyde to mixture of primary or secondary amines, palladium or platinum catalyst KAO CORPORATION (JP) 1988-07-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200155606-A1 CRISPR/RNA-GUIDED NUCLEASE SYSTEMS AND METHODS ZFR, ADAR, RNGTT DNM1 477/4885MEN1 2907/4885KMT2A 956/4885
US-11963982-B2 CRISPR/RNA-guided nuclease systems and methods ZFR, ADAR, RNGTT DNM1 477/4885MEN1 2907/4885KMT2A 956/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.