Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16492198 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1MAPTHTTGAA | |
| SCHEMBL16492192 | 0.80 | GRK6 (0.49) | SMN1; SMN2ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL1324549 | 0.76 | MTNR1B (0.51) | ALDH1A1L3MBTL1 | |
| SCHEMBL15793918 | 0.75 | AR (0.44) | ALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL30602475 | 0.75 | AR (0.44) | ALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL28754525 | 0.75 | GAA (0.54) | ALDH1A1MAPTLMNAHTTGAA | |
| SCHEMBL27618571 | 0.73 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL7329978 | 0.72 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1MAPTLMNAPKM | |
| SCHEMBL1326178 | 0.72 | LMNA (0.44) | SMN1; SMN2ALDH1A1MAPTLMNAPKM | |
| SCHEMBL11434557 | 0.71 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922733-A | ADMINISTERING TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY, DEPRESSION, EPILEPSY, OBSESSIVE COMPULSIVE DISORDERS, ANOREXIA, BULIMIA AND ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0770076-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996002537-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-01 | — | — | WO | disclosed |