Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432752 | 0.88 | MAOB (0.56) | NPC1RAB9AMAOBMAOABCHE | |
| SCHEMBL8434242 | 0.87 | GID4 (0.60) | MAOBMAOA | |
| SCHEMBL23440948 | 0.82 | MAOB (0.65) | NPC1RAB9AMAOBMAOAMEN1 | |
| SCHEMBL8431818 | 0.80 | MAOB (0.72) | MAOBMAOA | |
| SCHEMBL8434265 | 0.80 | PARP15 (0.58) | MAOBMAOA | |
| SCHEMBL8433725 | 0.79 | SCN9A (0.72) | MAOBMAOABCHE | |
| SCHEMBL11511833 | 0.78 | MAOB (0.58) | NPC1RAB9AMAOBMAOALMNA | |
| SCHEMBL8433399 | 0.75 | NPC1 (0.57) | NPC1RAB9AMAOBMAOALMNA | |
| SCHEMBL3971405 | 0.74 | NPC1 (0.56) | NPC1RAB9AMAOBMAOALMNA | |
| SCHEMBL15890891 | 0.74 | BCHE (0.65) | NPC1RAB9AMAOBMAOALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5945454-A | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives | PHARMACIA & UPJOHN, S.P.A. (IT) | 1999-08-31 | — | — | US | claimed |
| US-5945454-A | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives | PHARMACIA & UPJOHN, S.P.A. (IT) | 1999-08-31 | — | — | US | disclosed |