SCHEMBL8433416

SCHEMBL8433416

CC(=O)Nc1ccc2c(c1)C(C)CC2.CCCNCCC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.58
MAPT P10636 1/20 0.42
NAMPT P43490 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
CYP1A2 P05177 1/20 0.39
ADRA2A P08913 1/20 0.39
MAOA P21397 1/20 0.39
SLC6A2 P23975 1/20 0.39
HTR2C P28335 1/20 0.39
SLC6A4 P31645 1/20 0.39
HTR2B P41595 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
HTR1A P08908 1/20 0.39
ACHE P22303 2/20 0.39
BAZ2B Q9UIF8 1/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8436872 0.88 MTNR1A (0.45) MTNR1ACYP1A2NPC1RAB9AACHE
SCHEMBL8432637 0.87 MTNR1A (0.44) MTNR1AHTR1AACHE
Dimethylamine SCHEMBL8433853 0.87 MTNR1A (0.59) MTNR1AMAPTNAMPTL3MBTL1CHRNB2
SCHEMBL8432113 0.85 NPC1 (0.49) MTNR1AMAPTNPC1RAB9A
SCHEMBL8436353 0.84 NPC1 (0.49) NPC1RAB9A
SCHEMBL8432869 0.83 EPHX1 (0.51) MTNR1AALDH1A1
SCHEMBL8432408 0.83 RAB9A (0.51) NAMPTNPC1RAB9AHTR1A
SCHEMBL8436852 0.82 MTNR1A (0.38) MTNR1AADRA2AHTR1AACHE
Oxalic Acid SCHEMBL8432169 0.82 MTNR1A (0.39) MTNR1AACHE
SCHEMBL8697680 0.82 MTNR1A (0.36) MTNR1AADRA2ASLC6A2SLC6A4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5972964-A FOR TREATMENT OF CERTAIN PSYCHIC AND NEUROLOGIC DISORDERS SUCH AS PSYCHOSIS, ANXIETY DISORDERS, PANIC DISORDER, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, AGGRESSION H. LUNDBECK A/S (DK) 1999-10-26 US disclosed
US-5807889-A PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS H. LUNDBECK A/S (DK) 1998-09-15 US disclosed
EP-0673360-B1 AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES LUNDBECK & CO AS H (DK) 1998-08-26 EP disclosed
EP-0673360-A1 AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES H. LUNDBECK A/S (DK) 1995-09-27 EP disclosed
WO-1994013620-A1 AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES H. LUNDBECK A/S (DK) 1994-06-23 WO disclosed