Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27510623 | 0.92 | OPRM1 (0.51) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8298272 | 0.84 | HTR1A (0.56) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8303894 | 0.83 | HTR1A (0.57) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8299404 | 0.83 | HTR1A (0.57) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8303685 | 0.83 | HTR1A (0.50) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8298214 | 0.79 | HTR1A (0.54) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8304236 | 0.78 | HTR1A (0.53) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8297779 | 0.75 | HTR1A (0.75) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL27532215 | 0.75 | DRD2 (0.52) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8297150 | 0.71 | HTR1A (0.71) | HTR1AADRA1ADRD4ADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |