Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.39 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718461 | 0.88 | NPC1 (0.45) | SMN1; SMN2LMNANPC1RAB9AKMT2A | |
| SCHEMBL7491139 | 0.88 | CTSB (0.44) | SMN1; SMN2LMNAMMP13NPC1RAB9A | |
| SCHEMBL8434256 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2LMNANPC1RAB9APOLB | |
| SCHEMBL7489824 | 0.84 | THRB (0.40) | SMN1; SMN2LMNAMMP13NPC1RAB9A | |
| SCHEMBL8823569 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2LMNANPC1RAB9APOLB | |
| SCHEMBL7268595 | 0.77 | ALDH1A1 (0.41) | SMN1; SMN2LMNANPC1RAB9AKMT2A | |
| SCHEMBL8823524 | 0.76 | ALDH1A1 (0.36) | SMN1; SMN2LMNANPC1RAB9APOLB | |
| SCHEMBL8823589 | 0.75 | TUBB4A (0.50) | LMNANPC1RAB9AKMT2APOLB | |
| Methane SCHEMBL7498094 | 0.74 | NPC1 (0.46) | SMN1; SMN2LMNAMMP13NPC1RAB9A | |
| SCHEMBL7498087 | 0.74 | NPC1 (0.46) | SMN1; SMN2LMNAMMP13NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |
| US-5714508-A | INHIBITORS OF ANGIOTENSIN II | ROUSSEL UCLAF (FR) | 1998-02-03 | — | — | US | disclosed |