Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19629675 | 0.85 | HASPIN (0.37) | SMN1; SMN2HPGDCYP3A4MAPK1TSHR | |
| SCHEMBL17895105 | 0.80 | HPGD (0.48) | SMN1; SMN2HPGDMAPK1TSHRMEN1 | |
| SCHEMBL22224597 | 0.77 | HPGD (0.46) | SMN1; SMN2HPGDMAPK1TSHRMEN1 | |
| SCHEMBL1856394 | 0.75 | PDE3B (0.38) | SMN1; SMN2CYP3A4PDE3AMEN1LMNA | |
| SCHEMBL8258852 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDCYP3A4MAPK1TSHR | |
| SCHEMBL25702640 | 0.74 | NOS2 (0.44) | PDE3APDE3BS1PR4GRM5 | |
| SCHEMBL28012435 | 0.74 | PDE3B (0.41) | PDE3ADRD3ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL30525604 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDCYP3A4MAPK1TSHR | |
| SCHEMBL23251404 | 0.72 | GRM5 (0.49) | SMN1; SMN2HPGDMEN1LMNAKMT2A | |
| SCHEMBL10339250 | 0.72 | ALDH1A1 (0.36) | CYP3A4MAPK1TSHRPDE3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | SMN1; SMN2 3028/4885HPGD 156/4885CYP3A4 1491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.