Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191261 | 0.85 | HASPIN (0.40) | HASPINDYRK2SMN1; SMN2MAPK1PDE10A | |
| SCHEMBL8435367 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPK1ALDH1A1PDE3BPDE3A | |
| SCHEMBL191462 | 0.85 | HASPIN (0.37) | HASPINDYRK2SMN1; SMN2MAPK1PDE10A | |
| SCHEMBL28189540 | 0.83 | HASPIN (0.42) | HASPINDYRK2SMN1; SMN2MAPK1PDE10A | |
| Hydrochloric Acid SCHEMBL191647 | 0.83 | ALDH1A1 (0.38) | HASPINDYRK2SMN1; SMN2MAPK1PDE10A | |
| SCHEMBL11918960 | 0.78 | RAB9A (0.42) | SMN1; SMN2MAPK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL12819972 | 0.78 | MAPT (0.39) | SMN1; SMN2MAPK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL31214455 | 0.78 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL16921629 | 0.77 | ALOX5 (0.41) | SMN1; SMN2MAPK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL19780195 | 0.77 | MAPT (0.41) | SMN1; SMN2MAPK1PDE10AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331881-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. | 2020-10-22 | — | — | US | disclosed |
| WO-2017197555-A1 | FUSED PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE STIMULATORS | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331881-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, DLD, DPYD | HASPIN 3612/4885DYRK2 3671/4885SMN1; SMN2 3587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.