Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8435795 | 0.99 | L3MBTL1 (0.44) | L3MBTL1ATMTDP1RAB9ANPC1 | |
| SCHEMBL8433423 | 0.86 | TDP1 (0.45) | L3MBTL1TDP1RAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8434788 | 0.85 | TDP1 (0.44) | L3MBTL1TDP1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8433805 | 0.76 | NOTUM (0.57) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL8495699 | 0.76 | RAB9A (0.43) | L3MBTL1TDP1RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8437873 | 0.75 | NOTUM (0.56) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8432986 | 0.74 | TAAR1 (0.46) | L3MBTL1TDP1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8433601 | 0.74 | ALDH1A1 (0.35) | L3MBTL1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL8438754 | 0.74 | TSHR (0.49) | L3MBTL1TDP1NPC1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8435756 | 0.73 | TAAR1 (0.45) | L3MBTL1TDP1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |