Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 4/20 | 0.53 |
| ▸ | CTSB | P07858 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869702 | 0.89 | ALDH1A1 (0.54) | ALDH1A1LARS1MMP3KAT6ALMNA | |
| SCHEMBL5869715 | 0.89 | ALDH1A1 (0.54) | ALDH1A1LARS1MMP3KAT6ALMNA | |
| SCHEMBL5869706 | 0.89 | ALDH1A1 (0.54) | ALDH1A1LARS1MMP3KAT6ALMNA | |
| SCHEMBL8436817 | 0.88 | MMP9 (0.48) | MMP3GAA | |
| SCHEMBL8437064 | 0.84 | MMP3 (0.56) | ALDH1A1MMP3LMNAGAASMN1; SMN2 | |
| SCHEMBL5870434 | 0.78 | LARS1 (0.55) | ALDH1A1LARS1KAT6ALMNAGAA | |
| SCHEMBL5870107 | 0.78 | LARS1 (0.55) | ALDH1A1LARS1KAT6ALMNAGAA | |
| SCHEMBL5870439 | 0.78 | LARS1 (0.55) | ALDH1A1LARS1KAT6ALMNAGAA | |
| SCHEMBL5138984 | 0.76 | KDM4E (0.61) | ALDH1A1LARS1MMP3KAT6AMEN1 | |
| SCHEMBL15251693 | 0.76 | KDM4E (0.61) | ALDH1A1LARS1MMP3KAT6AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | CAPN1 1360/4885CTSB 438/4885ALDH1A1 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.