Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MYLK | Q15746 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018579 | 0.87 | MAPT (0.47) | ADORA3TSHRNPSR1MEN1KMT2A | |
| SCHEMBL8440174 | 0.83 | TSHR (0.61) | ADORA3TSHRHSD17B10KDM4EHPGD | |
| SCHEMBL8438113 | 0.83 | HPGD (0.60) | TSHRHSD17B10KDM4EHPGDNPSR1 | |
| SCHEMBL8442358 | 0.83 | TSHR (0.45) | TSHRHSD17B10KDM4EHPGDNPSR1 | |
| SCHEMBL8441182 | 0.78 | NPSR1 (0.44) | TSHRHSD17B10KDM4EHPGDNPSR1 | |
| SCHEMBL9368993 | 0.76 | ADORA3 (0.45) | ADORA3MEN1KMT2AADRA2AADRA2B | |
| SCHEMBL8438121 | 0.75 | TSHR (0.41) | TSHRHSD17B10KDM4EHPGDNPSR1 | |
| SCHEMBL9364563 | 0.75 | SIRT6 (0.38) | ADORA3TSHRHSD17B10KDM4EHPGD | |
| SCHEMBL9367544 | 0.74 | TSHR (0.47) | TSHRHSD17B10KDM4EHPGDNPSR1 | |
| SCHEMBL10787692 | 0.73 | KDM4E (0.51) | ADORA3TSHRHSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717036-B1 | Use of 5-acyl-1,4-dihydropyridines for the treatment of diseases of the CNS | BAYER AG (DE) | 1999-03-17 | — | — | EP | claimed |
| EP-0717036-A1 | Use of 5-acyl-1,4-dihydropyridines for the treatment of diseases of the CNS | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |