Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369053 | 0.85 | ALDH1A1 (0.39) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9364266 | 0.84 | SMN1; SMN2 (0.41) | MGLLCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9123428 | 0.83 | NPSR1 (0.54) | ADORA3ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9364552 | 0.79 | ALDH1A1 (0.40) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL1144551 | 0.77 | MGLL (0.62) | MGLLALDH1A1TDP1BCL9CTNNB1 | |
| SCHEMBL9364315 | 0.77 | NPSR1 (0.42) | ALDH1A1MAPTMEN1LMNAKMT2A | |
| SCHEMBL27882785 | 0.76 | MGLL (0.60) | MGLLALDH1A1TDP1BCL9CTNNB1 | |
| SCHEMBL8437356 | 0.76 | ADORA3 (0.42) | ADORA3ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL1958366 | 0.75 | MGLL (0.60) | MGLLCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9369027 | 0.75 | L3MBTL1 (0.44) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451654-A2 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1991-10-16 | — | — | EP | claimed |
| EP-0451654-B1 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1994-09-07 | — | — | EP | disclosed |
| EP-0451654-A2 | Use of N-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | BAYER AG (DE) | 1991-10-16 | — | — | EP | disclosed |