Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919255 | 0.82 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8438783 | 0.81 | L3MBTL1 (0.52) | NPC1GAAALDH1A1USP2HTT | |
| SCHEMBL8437981 | 0.80 | PLAU (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7920364 | 0.80 | ALDH1A1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8441006 | 0.79 | ALDH1A1 (0.43) | NPC1GAAALDH1A1USP2HTT | |
| SCHEMBL8442526 | 0.78 | TBXA2R (0.57) | GAAALDH1A1HTTLMNAMAPK1 | |
| SCHEMBL8437798 | 0.77 | ALDH1A1 (0.59) | GAAALDH1A1LMNASMN1; SMN2NPY5R | |
| SCHEMBL8437961 | 0.76 | MEN1 (0.54) | GAAALDH1A1USP2HTTLMNA | |
| SCHEMBL8440903 | 0.75 | ALDH1A1 (0.62) | ALDH1A1HTTMAPK1SMN1; SMN2TBXA2R | |
| SCHEMBL8437712 | 0.74 | CA1 (0.45) | NPC1RAB9AGAAALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955505-A | TREATING NERVE DEGENERATIVE DISORDERS | NIPPON SUISAN KAISHA, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |