Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | F13A1 | P00488 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 2/20 | 0.38 |
| ▸ | TGM1 | P22735 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438145 | 1.00 | HSD11B1 (0.41) | HSD11B1EPHX2SIGMAR1DPP8DPP9 | |
| SCHEMBL8438547 | 1.00 | HSD11B1 (0.41) | HSD11B1EPHX2SIGMAR1DPP8DPP9 | |
| SCHEMBL8440457 | 0.93 | TDP1 (0.41) | DPP8DPP9ALDH1A1LMNATDP1 | |
| SCHEMBL8104455 | 0.91 | HSD11B1 (0.37) | HSD11B1EPHX2SIGMAR1DPP8DPP9 | |
| SCHEMBL8576589 | 0.90 | HSD11B1 (0.38) | HSD11B1EPHX2SIGMAR1DPP8DPP9 | |
| SCHEMBL7455087 | 0.90 | CTRB1 (0.42) | ALDH1A1LMNAMAPTKMT2ARAB9A | |
| SCHEMBL7455094 | 0.90 | CTRB1 (0.42) | ALDH1A1LMNAMAPTKMT2ARAB9A | |
| SCHEMBL8102832 | 0.90 | CTRB1 (0.42) | ALDH1A1LMNAMAPTKMT2ARAB9A | |
| SCHEMBL8102837 | 0.90 | CTRB1 (0.42) | ALDH1A1LMNAMAPTKMT2ARAB9A | |
| SCHEMBL8437704 | 0.89 | CTSK (0.37) | HSD11B1EPHX2SIGMAR1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866564-A | STABILITY | SANKYO COMPANY, LIMITED (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0518558-B1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | SANKYO CO (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5712267-A | Carbapenem derivatives, their preparation and their use as antibiotics | SANKYO COMPANY,. LIMITED (JP) | 1998-01-27 | — | — | US | disclosed |
| EP-0518558-A1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | Sankyo Company Limited (JP) | 1992-12-16 | — | — | EP | disclosed |