Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442180 | 0.89 | MEN1 (0.44) | HTTHPGD | |
| SCHEMBL8442829 | 0.86 | MEN1 (0.45) | HTTNPSR1KDM4EALDH1A1TTR | |
| SCHEMBL8441897 | 0.86 | CCR2 (0.44) | — | |
| SCHEMBL8438680 | 0.86 | CXCL8 (0.43) | — | |
| SCHEMBL8059436 | 0.85 | NR1H4 (0.46) | TTR | |
| SCHEMBL8438239 | 0.85 | HTT (0.54) | HTTLMNANPSR1KDM4EALDH1A1 | |
| SCHEMBL8438253 | 0.84 | SLC9A1 (0.62) | — | |
| SCHEMBL8439756 | 0.83 | POLB (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL8439161 | 0.83 | IDO1 (0.42) | ALDH1A1IDO1 | |
| SCHEMBL8441913 | 0.82 | KDM4E (0.58) | LMNAKDM4ETTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708088-B1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0708088-A1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1996-04-24 | — | — | EP | disclosed |