Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.63 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.61 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.59 |
| ▸ | F2 | P00734 | 3/20 | 0.59 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.59 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | PLG | P00747 | 1/20 | 0.59 |
| ▸ | S100B | P04271 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454071 | 0.85 | F2 (0.52) | PRSS1TMPRSS2F2ST14PRSS2 | |
| SCHEMBL11086552 | 0.83 | PARP10 (0.61) | — | |
| SCHEMBL12989289 | 0.81 | PRSS1 (0.63) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL2170360 | 0.79 | CA12 (0.42) | MAOAACHE | |
| SCHEMBL12348319 | 0.78 | PRSS1 (0.76) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL11783118 | 0.77 | ALDH1A1 (0.46) | PRSS1ADRA2ACYP2D6 | |
| SCHEMBL8011558 | 0.77 | PKM (0.58) | — | |
| Hydrochloric Acid SCHEMBL11783188 | 0.76 | PRSS1 (1.00) | PRSS1TMPRSS2PRMT1F2ST14 | |
| Propamidine SCHEMBL231060 | 0.76 | TMPRSS2 (1.00) | PRSS1TMPRSS2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL11784186 | 0.76 | PRSS1 (0.77) | PRSS1TMPRSS2PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384362-B1 | Glycinderivatives | HOFFMANN LA ROCHE (CH) | 1999-12-15 | — | — | EP | claimed |
| US-5663297-A | OLIGOPEPTIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-09-02 | — | — | US | claimed |
| EP-0384362-A2 | Glycinderivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | claimed |
| EP-0384362-B1 | Glycinderivatives | HOFFMANN LA ROCHE (CH) | 1999-12-15 | — | — | EP | disclosed |
| US-5663297-A | OLIGOPEPTIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0384362-A2 | Glycinderivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |