Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409979 | 0.92 | CHRNA3 (0.62) | CHRNA3CHRNB2CHRNA4CHRNB1CHRNB4 | |
| Fumaric Acid SCHEMBL8437899 | 0.87 | CHRNB2 (0.53) | CHRNA3CHRNB2CHRNA4CHRNA7CHRNB1 | |
| Fumaric Acid SCHEMBL8437905 | 0.87 | CHRNB2 (0.53) | CHRNA3CHRNB2CHRNA4CHRNA7CHRNB1 | |
| SCHEMBL8435382 | 0.87 | CHRNB1 (0.64) | CHRNA3CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL8437800 | 0.76 | ALOX5AP (0.40) | CHRNB2CHRNA4 | |
| SCHEMBL4979209 | 0.74 | CHRNB2 (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL7911829 | 0.70 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNA7CHRNB1 | |
| SCHEMBL7911837 | 0.70 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNA7CHRNB1 | |
| SCHEMBL7407318 | 0.70 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNA7CHRNB1 | |
| SCHEMBL3961240 | 0.70 | CHRNB2 (0.65) | CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | disclosed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |