Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591740 | 0.75 | HDAC3 (0.43) | HDAC8MEN1KMT2A | |
| SCHEMBL8553163 | 0.74 | SLC1A2 (0.55) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9061912 | 0.73 | LMNA (0.40) | LMNA | |
| SCHEMBL8440093 | 0.72 | ITGB1 (0.39) | ALDH1A1POLBL3MBTL1GAAHPGD | |
| SCHEMBL10786573 | 0.69 | ALDH1A1 (0.68) | ALDH1A1POLBL3MBTL1PKMEPHX1 | |
| SCHEMBL8772608 | 0.69 | ALDH1A1 (0.42) | ALDH1A1TDP1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL27478255 | 0.69 | F2 (0.36) | ALDH1A1POLBGAAHPGDLMNA | |
| SCHEMBL8440095 | 0.69 | F2 (0.36) | ALDH1A1POLBGAAHPGDLMNA | |
| SCHEMBL8772523 | 0.68 | HCRTR1 (0.43) | ALDH1A1L3MBTL1GAAHSD17B10HPGD | |
| SCHEMBL8772387 | 0.68 | HMOX1 (0.40) | ALDH1A1POLBL3MBTL1PKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |