Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.56 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.56 |
| ▸ | CHRNG | P07510 | 1/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.56 |
| ▸ | CHRND | Q07001 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8437890 | 0.99 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA1 | |
| SCHEMBL6586231 | 0.87 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA1 | |
| SCHEMBL4155746 | 0.77 | LTA4H (0.79) | CHRNA3CHRNB4 | |
| SCHEMBL5332805 | 0.77 | LTA4H (0.79) | CHRNA3CHRNB4 | |
| SCHEMBL7901523 | 0.77 | LTA4H (0.79) | CHRNA3CHRNB4 | |
| SCHEMBL4650621 | 0.77 | LTA4H (0.48) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA1 | |
| SCHEMBL2229320 | 0.76 | SLC6A2 (0.69) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL6586316 | 0.76 | EP300 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA1 | |
| SCHEMBL6585946 | 0.75 | CHRNB2 (0.83) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA1 | |
| SCHEMBL6584663 | 0.75 | CHRNB2 (0.83) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | claimed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |