Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1199878 | 0.78 | KIF11 (0.42) | MAPTMEN1KMT2AMAPK1EGFR | |
| SCHEMBL15453937 | 0.72 | ARG1 (0.35) | GAA | |
| SCHEMBL10592441 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL20721585 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4194552 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6968286 | 0.70 | MAPT (0.38) | ALDH1A1MAPTPDGFRBPDGFRANOS1 | |
| SCHEMBL8302685 | 0.70 | NOS1 (0.36) | MAPTEGFRFGFR1NOS1DYRK1A | |
| SCHEMBL8927796 | 0.70 | CYP26A1 (0.38) | ALDH1A1KDM4EMAPTBLMTDP1 | |
| Hydrochloric Acid SCHEMBL6977245 | 0.70 | MAPT (0.37) | ALDH1A1MAPTPDGFRBPDGFRAHTT | |
| Hydrochloric Acid SCHEMBL2083483 | 0.69 | ALDH1A1 (0.60) | ALDH1A1HSD17B10CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944620-A1 | 2-IMIDAZOLINYLAMINOINDAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023609-A1 | 2-IMIDAZOLINYLAMINOINDAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |